Joshua Goldman
Joshua Goldman
min read · August 13, 2025 · Entertainment

Rosie O'Donnell's Shocking Transformation: How Mounjaro Turned Her Life Around!

Rosie O'Donnell displayed her slimmed down physique as she marveled at the results she had been acquiring thanks to the 'life saver' weight loss drug Mounjaro

ROSIE O'DONNELL'S SHOCKING TRANSFORMATION: HOW WEIGHT LOSS DRUG MOUNJARO IS CHANGING HER LIFE

In a jaw-dropping revelation, beloved actress and comedian Rosie O'Donnell has opened up about her incredible weight loss journey with the help of prescription medication Mounjaro. The 63-year-old former talk show host has been raving about the results she's achieved since starting the treatment in late 2022.

A SIZE 12 AND FEELING AMAZING

Rosie, pictured left in 2013, revealed in early 2023 that she shed 10 pounds thanks to Mounjaro

Rosie recently took to Instagram to share her dramatic transformation, proudly announcing that she's now a size 12 and crediting Mounjaro as a "life saver." In a stunning photo, she showed off her slimmed-down physique in a fitted black track suit, leaving fans and friends alike stunned. The mom-of-five shared the update with her followers, writing: "ok so went shopping to but a comfy lounge wear outfit for my 22 hour flight to australia- was undecided as i cant see myself in this new smaller body- cam n robin took this photo of me in the dressing room - i am shocked im a 12 - #mounjaro is a life saver."

FANS GO WILD OVER ROSIE'S TRANSFORMATION

The response from fans and friends has been overwhelming, with many echoing Rosie's sentiments about Mounjaro being a "life changer." Kristin Chenoweth was among those to congratulate the actress, writing: "You look amazing!" Another fan chimed in, "It is a life changing med! Not only does it help you lose weight but decreases the inflammation in your body so you feel so much better."

O'Donnell, pictured 2022, has also credited her home cooking for helping her lose the weight

ROSIE'S JOURNEY WITH MOUNJARO

Rosie's journey with Mounjaro began last year when she was prescribed the medication to manage her type 2 diabetes. In a TikTok video shared back in March, she explained that one of the side effects of taking Mounjaro is weight loss. However, Rosie revealed that the weight loss wasn't just due to the medication – it was also because she had recently switched from having a personal chef to cooking for herself and her child.

"I find it shocking," Rosie exclaimed in the video. "I really do. I find it completely shocking." The actress went on to reveal that since taking Mounjaro, she's not only lost weight but has also noticed improvements in her overall health and energy levels.

Rosie, pictured last year filming And Just Like That with Cynthia Nixon, has been taking Mounjaro since late 2022

ROSIE'S PRE- MOUJARO WEIGHT LOSS UPDATE

Rosie first revealed her weight loss progress back in January 2023, sharing with fans that she had lost an impressive 10 pounds during the holiday season. In a TikTok video, she explained how Mounjaro was helping her achieve this weight loss, saying: "Okay, so like two months ago, my doctor put me on... not Ozempic, Mounjaro? Something like that, and Repath." Rosie shared that she's been taking the medication consistently, combining it with healthier eating habits and increased physical activity.

ROSIE'S DIETARY CHANGES

Fans, including Kristin Chenoweth, praised Rosie's results

As part of her weight loss journey, Rosie has made significant changes to her diet. She's stopped drinking soda altogether, sticking to water instead. The actress has also reduced her sugar intake and shared that she's noticed a decrease in her appetite since starting Mounjaro.

"It's probably the meds, and I'm trying to move more," Rosie explained, "so all of those things combined, that's what it is."

Rosie cloaked her slimmer physique in a 'New York' outfit last month

She provided a weight loss update back in May with this photo (L) of her slimmer figure