Joshua Goldman
Joshua Goldman
min read · September 9, 2025 · Entertainment

Oprah Winfrey's Unrecognizable Transformation: The Ozempic Journey

Oprah Winfrey looked almost unrecognizable in her latest social media snap amid her weight loss journey

Oprah's Weight Loss Secrets EXPOSED: TV Queen, 71, Looks Almost Unrecognizable as She Bares All About Her Dramatic Transformation

In a shocking revelation, media mogul Oprah Winfrey has opened up about her dramatic weight loss journey, leaving fans speechless and speculating about her secrets to success. The 71-year-old television personality took to Instagram on Tuesday to share a stunning self-portrait, showcasing her slimmed-down physique in a colorful V-neck blouse and leather trousers. But what's got everyone talking is not just her svelte new look – it's the fact that she's finally come clean about using weight loss medication to achieve her goals.

For years, Oprah had been dogged by rumors that she was using medical aids to shed pounds, but she had always denied these allegations. However, in a candid interview with People last December, she revealed that she had indeed started taking GLP-1 drugs, type-2 diabetes medication that also helps with weight loss. And the results are nothing short of miraculous – Oprah has lost an astonishing 50 pounds!

On Tuesday, the 71-year-old television personality took to Instagram to share a self-portrait for her book club and, in doing so, showed off her slimmed down physique; pictured September 2008 in Los Angeles

But what's even more intriguing is the controversy surrounding her use of these medications. In a shocking U-turn, Oprah admitted to using the weight loss aid after years of criticizing those who rely on such treatments for their slimming needs. "I now use it as I feel I need it – as a tool to manage not yo-yoing," she explained. But this revelation has sparked heated debate among fans and critics alike.

Some have praised Oprah for her honesty and vulnerability, while others have accused her of hypocrisy. After all, didn't she once refer to weight loss medication as an "easy way out" and deny using it for her own weight loss needs? It seems that even the Queen of Talk shows isn't immune to criticism – especially when it comes to her highly publicized weight struggles.

But what's behind Oprah's decision to finally open up about her use of weight loss medication? According to sources close to the TV mogul, she was "done with the shaming" and felt empowered to share her truth. In an emotional interview with People, she revealed that her journey first began in 2021 after undergoing knee surgery and starting a new exercise routine. However, it wasn't until July 2023 that she decided to change her approach and use weight loss medication to manage her weight fluctuations.

She also turned off her comments amid fan discourse about her usage of weight loss medication, the name of which she has not yet disclosed; pictured June in New York City

Oprah's admission comes as no surprise given the high profile of her weight struggles over the years. At one point, she weighed a staggering 237 pounds – a far cry from her current svelte figure. But despite the criticism she faced, Oprah has always been an advocate for body positivity and self-acceptance.

However, it seems that even the most confident celebrities can struggle with their weight. In a candid interview on The Life You Want series, titled The State of Weight, Oprah opened up about her struggles with yo-yo dieting and how she's been able to overcome them using medical aid. "I realized I'd been blaming myself all these years for being overweight," she admitted. "And I have a predisposition that no amount of willpower is going to control."

So what can we learn from Oprah's dramatic weight loss transformation? For one, it's clear that even the most confident and successful individuals can struggle with their weight – and that seeking help is not always a sign of weakness. As for her secrets to success, Oprah has credited her new exercise routine and medical aid with helping her achieve her goals.

Her post comes after she open up about her body transformation and unveiling the secrets to her dramatic weight loss; pictured August 2019 in Los Angeles

In fact, she's so passionate about using GLP-1 drugs as a tool for managing weight fluctuations that she's even recommended it to others – although she's now chosen to use it herself. And judging by her latest Instagram post, it's clear that she's feeling empowered and confident in her own skin.

So what do you think, readers? Are you Team Oprah or do you believe she's being hypocritical about her use of weight loss medication? Share your thoughts with us in the comments below!

Sources:

The talk show host's admission was heavily criticized at the time as she had previously slammed using GLP-1 drugs, type-2 diabetes medication that also aids in weight loss; pictured April 2019 in Hollywood

  • The Scholarly Note (formerly Daily Mail), "Oprah Winfrey's Stunning Weight Loss Transformation Exposed"
  • People Magazine, "Oprah Winfrey Opens Up About Her Weight Loss Journey and Use of GLP-1 Drugs"

She explained that her health journey first began in 2021 following a getting surgery on her knee. 'After knee surgery, I started hiking and setting new distance goals each week,' she explained; pictured December 2023 in Los Angeles