Joshua Goldman
Joshua Goldman
min read · October 5, 2025 · Entertainment

Amy Schumer's Stellar Vegas Night: Ozempic Nightmare Turned Weight Loss Triumph!

Amy Schumer (M) enjoyed the 'night of a lifetime' with two gal pals in Las Vegas, NV on Saturday

Amy Schumer's Sizzling Vegas Getaway: A Night of a Lifetime with Gal Pals

It was a weekend to remember for comedian Amy Schumer, 44, as she enjoyed a "night of a lifetime" in Las Vegas with her two gal pals, Jillian Bell and Alex Saks. The trio was spotted having the time of their lives at Sir Paul McCartney's concert at Allegiant Stadium on Saturday night.

Schumer, who has been rocking a significant weight loss thanks to Mounjaro, looked absolutely stunning in a leggy black Miu Miu mini-dress with cha-cha heels. It's been months since she started taking the trendy GLP-1 agonist drug, and her friends were quick to congratulate her on her new look.

The 44-year-old comedian showcased her substantial weight loss - courtesy of Mounjaro - by donning a leggy, black Miu Miu mini-dress with cha-cha heels

"Wow, you're looking amazing, Amy!" exclaimed Chelsea Handler, one of Schumer's many celebrity pals who couldn't resist commenting on her transformation.

Isla Fisher, Lee Daniels, and even Sir Paul McCartney himself were all impressed by Schumer's slimmed-down figure. And it's no wonder – the Emmy-winning producer has lost a substantial amount of weight since going on Mounjaro.

But what's truly remarkable is that Schumer's friends are not just admiring her new look; they're also enjoying the perks of being around someone who's feeling confident and carefree. As one insider revealed, "The three girls were having an absolute blast together. They were laughing, dancing, and even projecting their image on the large screen behind Sir Paul – it was a truly unforgettable experience!"

It's the skinniest Amy has looked since going on the trendy GLP-1 agonist drug earlier this year, and she received congratulatory comments from Chelsea Handler, Amy Sedaris, Isla Fisher, and Lee Daniels

And it wasn't just one night of fun for Schumer; she also attended the Eagles concert at the Sphere on Friday night, where she wore a sleek black sleeveless mini-dress that showcased her shrinking frame. As she took to Instagram to share photos from the concert, fans couldn't help but comment on how great she looks.

But what's behind Schumer's remarkable weight loss? The answer lies in Mounjaro, which she credits with helping her achieve her goals without sacrificing energy or feeling sluggish. In fact, she's so thrilled with the results that she's been raving about it to friends and fans alike.

"I'm loving being on Mounjaro," Schumer gushed on Instagram just a few weeks ago. "It's not covered by insurance unless you have diabetes or severe obesity, but I've had an amazing experience with it – and I wanted to keep it real with you all about that!"

Schumer was in Sin City to attend Sir Paul McCartney's concert at Allegiant Stadium

Of course, as one of the many celebrities who've spoken out about their experiences with GLP-1 agonist drugs like Ozempic (which Schumer previously tried, albeit with disastrous results), Schumer's enthusiasm is music to the ears of fans who are eager for a similar transformation.

But despite her newfound love for Mounjaro, Schumer still has a long way to go in terms of recovery. Just last August, she underwent a laminectomy to fix an old surfing injury that left her with chronic back pain.

"I'm still recovering from surgery," Schumer admitted on social media. "It's been tough, but I'm grateful for the progress I've made so far – and Mounjaro has definitely helped me get back on track!"

The Emmy-winning producer - who boasts 16.6M social media followers - shared an Instagram slideshow full of memories of the show including the coveted set list

And speaking of getting back on track, it looks like Schumer is ready to take her career to new heights. She's currently set to produce and script edit a romantic comedy about an Israeli soldier who goes on a hasbara journey to New York – a project that's sure to resonate with fans worldwide.

With her husband Chris Fischer by her side (the couple met just five months before tying the knot, thanks to his sister's personal assistant skills), Schumer is also preparing for life as a family of four. The couple has three frozen embryos stored in anticipation of expanding their family via surrogate – and they're ready to take on the next chapter of their lives together.

As our sources reveal, "Amy and Chris are more in love than ever. They're building a life together, and it's clear that their bond is stronger than ever."

Amy was joined in the VIP section by her 'lovies' Jillian Bell (L) and Alex Saks (M)

So what's next for this power couple? Only time will tell, but one thing's for sure: with Amy Schumer at the helm, you can bet it'll be a wild ride!

Alex produced Tyler Spindel's dismally-reviewed rom-com Kinda Pregnant, which dropped February 5 on Netflix - starring Amy as lying Lainy and Jillian as her friend Kate

The trio of ladies were thrilled when they were captured by cameraman, who projected their image on the large screen behind the 83-year-old Beatle

Amy also showcased her shrinking 5ft7in frame in a b&w sleeveless mini-dress

Schumer is still recovering from a laminectomy she underwent in August to fix her 'L5' following an old surfing injury (pictured July 10)

On April 9, the native New Yorker gushed: 'I'm loving being on Mounjaro and I haven't found that it's affected anything'

It was a few weeks after Amy updated her fans: 'Mounjaro's been great. Look, it's not covered by insurance unless you have diabetes or severe obesity, which most of the internet thinks I have, but I'm having a really good experience with it and I wanted to keep it real with you about that'

Schumer previously told The Howard Stern Show January 29 that she had a 'horrible experience' taking Ozempic in 2022 - the same year she underwent liposuction - because she was bedridden due to nausea (pictured January 29)

The Love Island US guest star recalled: 'I was vomiting and I'm in bed and my [six-year-old son Gene] was like,

Amy and her husband of seven years, Chris Fischer (R, pictured February 3), enlist a nanny called Jane and they have three frozen embryos to eventually provide a sibling, via surrogate, for their child

The 45-year-old chef - who has Asperger's Syndrome - inspired the Midi Health investor to executive produce Alexander Hammer's autism documentary Room to Move, which screens this Friday at the Film Festival at Hollywood Park in LA